Coinbase reported weak Q1 2026 earnings, causing shares to drop 4% after hours. However, institutional transaction revenue rose 31%, prediction markets rapidly reached $100 million annualized revenue, and retail derivatives passed $200 million. Coinbase set a new all-time high in crypto trading volume market share, gaining ground on competitors despite overall market weakness. The company’s future hinges on whether fast-growing products like derivatives and prediction markets can offset declining spot trading fees. Tom Lee’s Bitmine is slowing Ethereum purchases as it nears its target of 5% of total ETH supply, now holding about 4.29%. With 84% of holdings staked, Bitmine earns $297 million annually. Lee’s reduced buying removes a key source of institutional demand. Amazon Web Services, in partnership with Coinbase and Stripe, launched a system enabling AI agents to use stablecoins for autonomous payments in enterprise settings. This marks the first native crypto integration for a major cloud provider, with expansion into broader transactions planned. Tether introduced QVAC MedPsy, a medical AI model that runs fully on smartphones without internet, offering psychiatric and clinical assessments. It outperforms much larger models, supporting rural and privacy-sensitive medical environments.